• Study of Coiling of Unruptured Aneurysm

    Aspirin 325mg for Prevention of Thromboembolic Events
  • Inclusion Criteria:

    Inclusion Criteria: 1. Unruptured intracranial aneurysm suitable for coiling-only (primary coiling or balloon-assisted) as a primary treatment. 2. Functionally independent at baseline (modified Rankin scale <3). 3.Informed consent and availability of the subject for the entire study period.

Brief Summary:

This trial is a is a prospective, randomized (1:1) placebo-controlled, clinical trial with blinded endpoint assessment of 440 participants with unruptured brain aneurysm planned for endovascular treatment using coiling-only approach (primary coiling or using balloon-assistance but not stenting) to test if oral acetylsalicylic acid (325 mg/ day for a total of 5 days) is superior placebo in preventing clinical and silent strokes. The primary outcome is a clinical or silent stroke at the time of discharge assessed by clinical examination and MRI brain. Participants will return to the clinic or be contacted by phone for the end of study procedures on Day 90 to collect functional outcome data.

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Investigators

Dr. Mohammed Almekhlafi   &   Dr. Mayank Goyal